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Tylenol Side Effects |
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Tylenol Review Questions and Answers
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| Trade Name: Tylenol |
| Generic Names: Acetaminophen |
| What are the side effects for Tylenol? |
| Side effects: When Tylenol is used as prescribed there are very few side effects. When acetaminophen is taken at large dose it can result in toxic effects resulting from interaction with sulfhydryl groups of proteins. This generally occurs when glutathione reserves are exhausted. The symptoms result because of liver dysfunction, and are characterized by anorexia, abdominal pain, nausea, vomiting, and eventually liver failure |
| How is Tylenol metabolized? |
| Acetaminophen is metabolized by the liver. |
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Adverse events in people taking with Tylenol |
| Gastrointestinal | Nausea, vomiting, liver failure |
| Neurological | ... |
| Musculoskeletal | ... |
| Genitourinary | ... |
| Dermatologic | ... |
| Psychiatric | ... |
| Neurologic | ... |
| Pharmacology - Acetaminophen |
| Question: |
| What are the three phases of acetaminophen poisoning? |
| Answer: |
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Phase I -30 min - 24 hours (Anorexia, nausea vomiting) Phase II -1 - 4 days (Mild RUQ tenderness, Abnormal LFT's) Phase III - 3 - 5 days after ingestion (Anorexia, nausea, pain, malaise, stupor, death) |
| Question: |
| What are considered toxic doses of acetaminophen in an adult? |
| Answer: |
| Doses of > 10 grams are considered toxic. In many patients it is difficult to determine the dose taken. Generally, the serum acetaminophen levels are taken at least 3 hours post ingestion and plotted on the Rumack-Matthew nomogram to determine the probability of hepatic toxicity |
| Question: |
| When do peak concentrations of acetaminophen occur? |
| Answer: |
| The peak levels of acetaminophen occur approximately 4 hours after an overdose and approximately 1 hour after a prescribed normal dose |