Side Effects of Aspirin

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Aspirin Review Questions and Answers
Trade Name:  Aspirin
Generic Names:  Acetylsalicylic Acid
What are the side effects of Aspirn?
 Aspirin has a multitude of side effects including acid -base abnormalities, ringing in the ears (tinnitus), vertigo, hearing loss, kidney failure, gastrointestinal bleeding, and gastritis.
How is aspirin excreted?
Aspirin irreversibly inhibits platelet function. Approximate 10% of platelets are replaced each day therefore the effects of aspirin on platelet function will last for approximately 10 days.
 

Adverse events in people taking with Dolobid

 

Gastrointestinal Gastritis, gastrointestinal bleeding
Neurological Tinnitus, vertigo, hearing loss
Cardiac ...
Genitourinary Anion gap metabolic acidosis
Pulmonary Respiratory alkalosis
Endocrine ...
Hematologic Platelet dysfunction and bleeding
Pharmacology - Aspirin
Question:
What is the mechanism of aspirin?
Answer:
Aspirin irreversibly acetylates cyclooxygenase.
Question:
How does an aspirin overdose cause a metabolic acidosis?
Answer:
Aspirin overdose results in uncoupling of oxidative phosphorylation as well as uncoupling of the Krebs cycle leading to a metabolic acidosis.
Question:
What is the effect of aspirin overdose on respiratory centers of the brain?
Answer:
Aspirin overdose results in increased sensitivity in respiratory centers, increased rate and depth resulting in a respiratory alkalosis. 
Question:
What can be done in circumstances of aspirin overdose to decrease reabsorption?
Answer:
Alkalinizing urine can decrease reabsorption.