Side Effects of Flecainide

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Flecainide Review Questions and Answers
Trade Name:  Side effects of Tambocor
Generic Names:  Side effects of Flecainide
What is the mechanism of Flecainide?
Flecainide is a class Ic antiarrhythmic that works by blocking the sodium channels, resulting in depression of the phase 0 the polarization and decreased induction velocity at the Perkinge cells. At the pacemaker cells of flecainide works to decrease the slope of phase 4 and increase the threshold for depolarization.
What are the contraindications to Flecainide?
Flecainide should not be used in patients with second degree or third-degree or bifascicular heart block. Flecainide may decrease the effectiveness of pacemakers. Flecainide should not be used in people with a history of structural heart disease.
 Adverse events in people taking with Flecainide
Gastrointestinal ....
Neurological ...
Cardiac Arrhythmias
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Endocrine  
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Pharmacology - Flecainide
Question:
What is the mechanism of Flecainide?
Answer:
Flecainide causes a decrease in intracardiac conduction throughout the heart with increased effects on the HIS-perkinge conduction.
Question:
When is Flecainide contraindicated?
Answer:
Flecainide is contraindicated in patients with a history of second or third degree AV block. It is also contraindicated in patients with a right bundle branch block when associated with a left hemiblock.
Question:
What is the plasma half-life of Flecainide?
Answer:
 The plasma half-life of a single dose of Flecainide is approximately 20 hours, however with multiple doses this half-life will increase to three to five days
Question:
When do peak plasma levels occur after taking an oral dose of Flecainide?
Answer:
The peak plasma levels after taking a dose of Flecainide occur in approximately three hours.