Side Effects of Methotrexate

Side Effects of Methotrexate

Methotrexate Review Questions and Answers

Generic Names: Side effects of Methotrexate

Methotrexate is renally excreted.

Side effects of Methotrexate:

Gastrointestinal	Gastrointestinal hemorrhagic enteritis, liver damage, accumulation and ascites
Hematologic	Myelosuppression
Neurological	Arachnoiditis
Pulmonary	Pulmonary damage, accumulation in pleural effusions

Pharmacology of Methotrexate:

Question:

What is the mechanism of methotrexate?

Answer:

Methotrexate is a folic acid analog which inhibits dihydrofolate reductase, thus depleting dTMP and
inhibiting DNA synthesis. It is specific for S phase

Question:

Is there a potential interaction between trimethoprim and Methotrexate?

Answer:

Yes, there is some data that trimethoprim, when given to patients receiving methotrexate, can have
increased myelosuppression when compared to those given methotrexate without trimethoprim